Fast-atom bombardment and tandem mass spectrometry of macrolide antibiotics
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چکیده
منابع مشابه
Fast - atom - bombardment mass spectrometry
A detailed study of the mass spectra of peptides produced by the new technique of fast-atom bombardment is reported. Molecular weights of unmodified peptides containing up to 21 amino acids have been determined. In favourable cases, the molecular-weight determination may be made on as little as 0.1 nmol of sample. Positive-ion and negative-ion spectra are obtained with equal facility. With samp...
متن کاملFAST ATOM BOMBARDMENT MASS SPECTROMETRY (FABMS) ANALYSIS OF AN N- TERMINAL - BLOCKED PEPTIDE
FABMS analysis of T-lb peptide before and after one cycle of Edman degradation indicated an unblocked N-terminal Thr residue for this tryptic peptide. In contrast , our data showed a molecular protonated ion, MH + for T- la peptide at 655 mass units (mu) which is 42 mu higher than the MH ion of T- 1b peptide. In addition, T- la peptide was not amenable to one cycle of manual Edman degrada...
متن کاملContinuous-flow fast atom bombardment mass spectrometry.
The continuous-flow fast atom bombardment probe performs equally well with or without a high-performance liquid chromatography column producing clean spectra containing little or no background noise. Its function as a liquid chromatography-mass spectrometry interface for labile and involatile samples has been illustrated with reference to dansylated amino acids. The versatility of the new probe...
متن کاملCharacterization of novel antibiotics of the triostin group by fast atom bombardment mass spectrometry.
The quinoxaline antibiotics are cyclic depsipeptides characterized by the presence of two heterocyclic aromatic chromophores and a cross-bridge, which is either a dithioacetal (quinomycins) or a disulphide (triostins). In the naturally-occurring members of this class the chromophores are both quinoxaline-2-carboxyl (shown as the parent acid in 1). There are natural variants in the class due to ...
متن کاملDifferentiation of isotopically labeled nucleotides using fast atom bombardment tandem mass spectrometry.
(21) Handbook of Chemistry and Physics, 53rd ed.; CRC Press: Cleveland, OH, 1972. (22) Corbridge, D. E. C. Phosphorus; Elsevier: New York, 1980; p 118. (23) Duval, C. Anal. Chim. Acta 1950, 4 . 159. (24) McLaren, J. W.; Wheeler, R. C. Ana/yst (London) 1977, 702. 542. (25) Salmon, S. G.; Davis, R . H., Jr.; Holcombe, J. A. Anal. Chem. 1981, 53 , 324. (26) Sedykh, E. M.; Belyaev, Yu. I . Zh. Anal...
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ژورنال
عنوان ژورنال: Journal of the American Society for Mass Spectrometry
سال: 1994
ISSN: 1044-0305,1879-1123
DOI: 10.1016/1044-0305(94)85028-3